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Xpert® vanA/vanB
Rapid VRE screening for active outbreak prevention and control in around 48 minutes
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10 Tests
GXVANA/B-CE-10
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The Need
- Vancomycin Resistant Enterococci (VRE) are a growing public health threat and pose a risk to patient safety in healthcare facilities1
- In healthcare settings, colonized patients and environmental contamination contribute to VRE spread1
- High-risk patients colonized with VRE have 24 times the increased infection risk2
- Infections caused by VRE are associated with high mortality3
- VRE has an impact on patient length of stay, and in turn, hospitalization costs3
1 Levitus M. et al. Vancomycin-Resistant Enterococci. StatPearls July 17, 2023. https://www.ncbi.nlm.nih.gov/books/NBK513233/?report=reader#_NBK513233_pubdet. Accessed December 11, 2023
2 Alevizakos M, et al. Colonization with vancomycin-resistant enterococci and risk for bloodstream infection among patients with malignancy: a systematic review and meta-analysis. Open Forum Infect Dis. 2016 Dec;4(1):ofw246.
3 Eichel V,M, et al. Epidemiology and outcomes of vancomycin-resistant enterococcus infections: a systematic review and meta-analysis. Journal of Hospital Infection 141 (2023) 119e128
2 Alevizakos M, et al. Colonization with vancomycin-resistant enterococci and risk for bloodstream infection among patients with malignancy: a systematic review and meta-analysis. Open Forum Infect Dis. 2016 Dec;4(1):ofw246.
3 Eichel V,M, et al. Epidemiology and outcomes of vancomycin-resistant enterococcus infections: a systematic review and meta-analysis. Journal of Hospital Infection 141 (2023) 119e128
The Solution
- The Xpert vanA/vanB test is a rapid and accurate method for detection of VRE colonization among high-risk admissions and for screening during outbreaks of VRE
- Fast, active screening of high-risk patients to prevent the spread of VRE and better manage colonization in healthcare settings
The Impact
- The Xpert vanA/vanB test facilitates more efficient infection control surveillance programs:4
– 93% reduction of turn around time from 70.5h with chromogenic agar culture to 4.6h
– High negative predictive value allows for better management of non-colonized patients
– Decreased the number of contact patients thereby preventing VRE transmission
– 94% reduction in overall cost (€14,302 with culture vs €870) - Compared to culture, faster time to result may support more effective patient management: more isolation and transmission risk days saved5
– 141 saved isolation days and 292 saved transmission risk days
4 Birgand G, et al. Lucet JC. Rapid detection of glycopeptide-resistant enterococci: impact on decision-making and costs. Antimicrobial Resistant and Infection Control.
2013 Nov ; 2:30.
5 Holzknecht BJ, Hansen DS, Nielsen L, Kailow A, Jarløv JO. Screening for vancomycin-resistant enterococci with Xpert® vanA/vanB: diagnostic accuracy and impact on
infection control decision making. New Microbes New Infect. 2017 Jan 12;16:54-59
2013 Nov ; 2:30.
5 Holzknecht BJ, Hansen DS, Nielsen L, Kailow A, Jarløv JO. Screening for vancomycin-resistant enterococci with Xpert® vanA/vanB: diagnostic accuracy and impact on
infection control decision making. New Microbes New Infect. 2017 Jan 12;16:54-59
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